I am really keen to shift my Maidsafe onto my Ledger Nano S. I could theoretically do this, because I could send my Maidsafe to any bitcoin address that I control. However, if I wanted to then send my Maidsafe, I would have to expose my private key to the internet, which would completely defeat the purpose of having a hardware wallet.
You can build open source apps for the Ledger Nano S. For instance, I currently have a Dash app on my Ledger. As far as I know, building a new GUI to support Ledger applications is not necessary, because they run with either the Ledger Wallet Bitcoin or Ethereum GUI for Chrome. So the work is primarily centred around constructing the architecture to install onto the Ledger Nano itself.
I am aware that the team at Maidsafe is currently working flat out to deliver the project, and we do not want to distract them from their goal. I therefore wonder if anyone in the community has the skills to build a Maidsafe app for the Ledger? If there is enough demand for it, the community could put up some Maidsafe as payment for the services of whoever builds the app.